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PAST WORK

Past Work

 A small selection of my previous work is featured below.

EDUCATION

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Projected Graduation 2025

Indiana University School of Medicine

Doctor of Philosophy

2016

Loyola University

Master of Science: Molecular Biology

2011

University of Mississippi

Bachelor of Science: Biology

GRANTS & AWARDS

Graduate Student Travel Fellowship - IU School of Medicine Dept of Microbiology and Immunology: May 2024

Poster Award - IU School of Medicine Dept of Microbiology and Immunology Annual Retreat: May 2024

Shrigley/Broxmeyer Graduate Student Research Award - IU School of Medicine Dept of Microbiology and Immunology: October 2024 "In Recognition of Outstanding Scientific Research Accomplishments."

2023

NIH T32 Institutional Training Grantee (NIH T32 5T32AI060519): January 2023- Present

AAI Trainee Abstract Award: May 2023

Poster Award - Wells Center for Pediatric Research Annual Retreat: August 2023

2022

IUPUI Graduate Student Travel Fellowship - For travel to “The Human Microbiome: Ecology and Evolution” Keystone Symposium: December 2022

Publications

PUBLICATIONS

Lajiness, J.D., Bloodworth, J.C., Blankenship, R.L., Kosins, A.E., Cook-Mills, J.M. (2024) Dendritic cell-specific deletion of PKCδ in offspring of allergic mothers prevents the predisposition for development of allergic lung inflammation in offspring. J Leukoc Biol. 

Walker, M.T., Bloodworth, J.C., Kountz, T.S., McCarty, S.L., Green, J.E., Ferrie, R.P., Campbell, J.A., Averill, S.H., Beckman, K.B., Grammer, L.C., Eng, C., Avila, P.C., Farber, H.J., Rodriguez-Cintron, W., Rodriguez-Santana, J.R., Serebrisky, D., Thyne, S.M., Seibold, M.A., Burchard, E.G., Kumar, R., Cook-Mills, J.M. (2024) 5-HTP inhibits eosinophilia via intracellular endothelial 5-HTRs; SNPs in 5-HTRs associate with asthmatic lung function. Front Allergy. 

Damron. C.L., Bloodworth, J.C., Hoji, A., Casasnovas, J., Kua, K.L., Cook-Mills, J.M. (2024) Increased Allergic Inflammation and Decreased Lung Insulin Sensitivity in Offspring of Obese Allergic Mothers. J Leukoc Biol. 

Bloodworth, J.C., Hoji, A., Wolff, G., Mandal, R.K., Schmidt, N.W., Deshane, J.S., Morrow, C.D., Kloepfer, K.M., Cook-Mills, J.M. (2023). Dysbiotic lung microbial communities of neonates from allergic mothers confer neonate responsiveness to suboptimal allergen. Front Allergy, Mar 10;4:1135412. doi: 10.3389/falgy.2023.1135412. PMID: 36970065; PMCID: PMC10036811.

Cabanov, A., Flood, B. A., Bloodworth, J. C., Higgs, E. F., Fessler, J., Leung, M. Y. K., Cron, K. R., Trujillo, J., Pyzer, A. R., Rouhani, S., Strohbehn, G., Heiss, B., Ratain, M., Reid, P., Yeo, K. J., Sweis, R. F., Zha, Y., Gajewski, T. F. (2020) Abstract S04-02: Treatment with tocilizumab does not inhibit induction of anti-COVID-19 antibodies in patients with severe SARS-CoV-2 infection. Clinical Cancer Research, (26) (18 Supplement) S04-02; DOI: 10.1158/1557-3265. COVID-19-S04-02

Strohbehn, G. W., Heiss, B. L., Rouhani, S. J., Trujillo, J. A., Yu, J., Kacew, A. J., Higgs, E. F., Bloodworth. J. C., Cabanov, A., Wright, R. C., Koziol, A. K., Weiss, A., Danahey, K., Karrison, T. G., Edens, C. C., Bauer, Ventura, I., Pettit, N. N., Patel, B. K., Pisano, J., Strek, M. E., Gajewski, T. F., Ratain, M. J., Reid, P. D. (2021). COVIDOSE: A Phase II Clinical Trial of Low-Dose Tocilizumab in the Treatment of Noncritical COVID-19 Pneumonia. Clinical Pharmacology & Therapeutics, 109 (3):688-696. doi: 10.1002/cpt.2117. Epub 2020 Dec 10. PMID: 33210302; PMCID: PMC7753375.

Sweis, R. F., Golan, S., Barashi, N., Hill, E., Andolfi, C., Werntz, R. P., Bloodworth, J. C., Steinberg, G. D. (2019). Association of the commensal urinary microbiome with response to Bacillus Calmette-Guérin (BCG) immunotherapy in nonmuscle invasive bladder cancer. Journal of Clinical Oncology, 37(7_suppl), 423-423. doi:10.1200/jco.2019.37.7_suppl.423

Andolfi, C., Bloodworth, J. C., Papachristos, A., Sweis, R. F. (2020). The Urinary Microbiome and Bladder Cancer: Susceptibility and Immune Responsiveness. Bladder Cancer, 6(3):225-235. doi: 10.3233/BLC-200277. PMID: 33195783; PMCID: PMC7605348.

Shah, N., Kumar, S., Zaman, N., Pan, C.C., Bloodworth, J.C., Lei, W., Streicher, J. M., Hempel, N., Mythreye, K., Lee, N. Y. (2018). TAK1 activation of alpha-TAT1 and microtubule hyperacetylation control AKT signaling and cell growth. Nature Communications, 27;9(1):1696. doi: 10.1038/s41467-018-04121-y.

Higgs, E. F., Flood, B. A., Pyzer, A. R., Rouhani, S.J., Trujillo J. A., Cron, K. R., Cabanov, A., Fessler, J., Bloodworth. J. C., Beavis, K., Yeo, K. J., Sweis, R. F., Zha, Y., Gajewski, T. F. (2020) Abstract PO-067: Tissue banking from patients with SARS-CoV-2 (COVID-19) infection. Clinical Cancer Research, (26) (18 Supplement) PO-067; DOI: 10.1158/1557-3265.COVID-19-PO-067

Pandya, K., Wyatt, D., Gallagher, B., Shah, D., Baker, A., Bloodworth, J. C., Zlobin. A., Pannuti, A., Green. A., Ellis, I.O., Filipovic, A., Sagert, J., Rana. A., Albain, K.S., Miele, L., Denning, M. F., Osipo, C. (2015). PKC  Attenuates Jagged-1-Mediated Notch Signaling in ErbB-2-Positive Breast Cancer to Reverse Trastuzumab Resistance. Clinical Cancer Research, 22(1), 175-186. doi:10.1158/1078-0432.ccr-15-0179

Kumar, S., Pan, C. C., Bloodworth, J. C., Nixon, A. B., Theuer, C., Hoyt, D. G., & Lee, N. Y. (2013). Antibody-directed coupling of endoglin and MMP-14 is a key mechanism for endoglin shedding and deregulation of TGF-β signaling. Oncogene, 33(30), 3970-3979. doi:10.1038/onc.2013.386

Pan, C. C., Bloodworth, J. C., Mythreye, K., & Lee, N. Y. (2012). Endoglin inhibits ERK-induced c-Myc and cyclin D1 expression to impede endothelial cell proliferation. Biochemical and Biophysical Research Communications, 424(3), 620-623. doi:10.1016/j.bbrc.2012.06.163

Bloodworth J.C., Osipo C. (2018) The Role of Notch in Breast Cancer. In: Miele L., Artavanis-Tsakonas S. (eds) Targeting Notch in Cancer. Springer, New York, NY

Zlobin, A., Wyatt, D., Bloodworth, J. C., Hilsenbeck, S., Fuqua, S., Miele, L., Albain, K. S., Osipo, C. (2016). Abstract LB-121: DAXX is a novel Notch-1 gene target and biomarker of GSI-sensitivity in ER breast cancer. Cancer Research, 76(14 Supplement). doi:10.1158/1538-7445.am2016-lb-121

Pan, C. C., Kumar, S., Shah, N., Bloodworth, J. C., Hawinkels, L. J., Mythreye, K., Hoyt, D. G. Lee, N. Y. (2015). Endoglin Regulation of Smad2 Function Mediates Beclin1 Expression and Endothelial Autophagy. Journal of Biological Chemistry, 290(24), 14884-14892. doi:10.1074/jbc.m114.630178

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